The idea of meaningful use, mandated by the American Recovery and Reinvestment Act, has been whittled down into defining the enigmatic term meaningful. In this search, discussions within the Office of the National Coordinator for Health IT and the Association of Medical Directors of Information Systems (AMDIS) have focused on the practice of medicine, not the implementation of IT. If the meaningful use of information systems does not have an obvious and profound impact on the safety and quality of healthcare, then it ceases to have meaning.